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Dissanayake S, Zheng H, Dreyer G, Xu M, Watawana L, Cheng G, Wang S, Morin P, Deng B, Kurniawan L, et al.

EVALUATION OF A RECOMBINANT PARASITE ANTIGEN FOR THE DIAGNOSIS OF LYMPHATIC FILARIASIS.

Am J Trop Med Hyg. 1994 Jun;50(6):727-34.

ABSTRACT

We evaluated the usefulness of a recombinant parasite antigen (recSXP1) for the serologic diagnosis of lymphatic filariasis. A large proportion of sera from microfilaremic donors living in five different endemic countries (356 of 446 [80%]) contained IgG antibodies to recSXP1, as do sera from approximately 33% of amicrofilaremic patients with acute filarial disease and/or indirect evidence of active filarial infection. Exposure to filarial worms per se does not appear sufficient to elicit an anti-SXP1 antibody response. Thus, this serologic test identifies a large proportion of persons with active lymphatic filariasis among residents of endemic areas.