Dreyer, G. & Norões, J.
DIETHYLCARBAMAZINE IN THE TREATMENT OF BANCROFTIAN FILARIASIS.
Revista da Sociedade Brasileira de Medicina Tropical, 30(3):229-240, 1997.
The authors presented a detailed review about
the tratment of bancr oftian filariasis with
diethylcarbamazine. The interesting aspects about
the drug discovery and the basic concepts about its
pharmacology were reported in a summarised form.
On the other hand, emphasis was made about the
speculation done by several authors about the
intringuing findings regarding its efficacy reported
in the literature. Latter, it was brought the new
advances about the disease, as for example, the
visualization by ultrasound of living Wuchereria
bancrofti adult worm on its natural host — the
human being. This made possible the comprehension
of several paradoxical issues reported, focusing the
treatment of infection using diethylcarbamazine. So
far, because of the lack of ideal drug with micro and
macrofilaricidal properties, together with the new
understand about the disease and the new
parameters for monitoring the efficacy of the drug,
diethylcarbamazine has back its importance
conquered at the begin of its discovery, almost fifth